The Federle Lab

Discovering Languages of Pathogens...

Chang, J.C., B. LaSarre, J.C. Jimenez, C. Aggarwal, and M.J. Federle. Two Group A Streptococcal Peptide Pheromones Act Through Opposing Rgg Regulators to Control Biofilm Development. PLoS Pathog. 7(8): e1002190. doi:10.1371/journal.ppat.1002190. PDF


LaSarre, B. and M.J. Federle. 2011. Regulation and Consequence of Serine Catabolism in Streptococcus pyogenesJournal of Bacteriology. 193(8): 2002-2012. PDF


Mashburn-Warren, L., D.A. Morrison, and M.J. Federle. 2010. A novel double-tryptophan peptide pheromone controls competence in Streptococcus spp. via an Rgg regulator. Mol Microbiol, 78(3):589-606. PMID: 20969646. This article was featured in a MicroCommentary in same issue. PDF


 Federle, Michael J.  2009. Autoinducer-2 Based Chemical Communication in Bacteria: Complexities of Interspecies Signaling. In Bacterial Sensing and Signaling, Editors Raymond Schuch and Mattias Collin. Karger Publishing. 16:18-32. PDF


Neiditch, M.B., M.J. Federle, A.J. Pompeani, R.C. Kelly, D.L. Swem, P.D. Jeffrey, B.L. Bassler, and F.M. Hughson.  2006. Autoinducer-2-induced asymmetry regulates LuxPQ quorum Sensing signal transduction. Cell. 126(6):1095-108. PDF


Neiditch, M.B., M.J. Federle, S.T. Miller, B.L. Bassler, F.M. Hughson. 2005. Regulation of LuxPQ receptor activity by the quorum sensing signal autoinducer-2.  Molecular Cell. 18(5):507-18.


Semmelhack, M.F., S.R. Campagna, M.J. Federle, and B.L. Bassler. 2005. An Expeditious Synthesis of DPD and Boron Binding Studies.  Organic Letters.  7(4):569-72.


Semmelhack, M.F., S.R. Campagna, C. Hwa, M.J.Federle, and B.L. Bassler. 2004. Boron binding with the quorum sensing signal AI-2 and analogues. Organic Letters.  6(15):2635-7.


Federle, M.J. and B.L. Bassler. 2003. Interspecies communication in bacteria. Journal of Clinical Investigation. 112(9):1291-1299.


Federle, M. J. and J.R. Scott. 2002. Identification of binding sites for the group A streptococcal global regulator CovR. Molecular Microbiology. 43(5), 1161-72.


Graham, M.R., L.M. Smoot, C.A. Migliaccio, K. Virtaneva, D.E. Sturdevant, S.T. Porcella, M. J. Federle, G.J. Adams, J.R. Scott, and J.M. Musser. 2002. Virulence control in group A Streptococcus by a two-component gene regulatory system: global expression profiling and in vivo infection modeling. Proc. Nal. Acad. Sci. USA. 99(21):13855-13860.


Benfang, L., F.R. Deleo, N.P. Hoe, M.R. Graham, S.M. Mackie, R.L. Cole, M. Liu, H.R. Hill, D. E. Low, M. J. Federle, J.R. Scott, and J.M. Musser. 2001. Evasion of human innate and acquired immunity by a bacterial homologue of CD11b that inhibits opsonophagocytosis. Nature Medicine. 7(12):1298-1305.


Federle, M.J., K.S. McIver, and J.R. Scott. 1999. A response regulator that represses the transcription of several virulence operons in the group A Streptococcus. Journal of Bacteriology. 181:3649-3657.


Eichenbaum, Z., M.J. Federle, D. Marra, W.M. DeVos, O.P. Kuipers, M. Kleerebezem, and J. R. Scott. 1998. Use of the lactococcal nisA promoter to regulate gene expression in gram-positive bacteria: comparison of induction level and promoter strength. Applied and Environmental Microbiology. 64: 2763-2769.